After a point, there's no reason to increase memory usage further.
dbcache is useful up until the point where you have the entire UTXO in memory (4GB+ in 2021), and then increasing it further does not a lot other than increasing the time to shutdown the node safely (up to many minutes on a slow disk)
maxmempool will increase performance by allowing more transactions (and their validity) to be ready for their inclusion in a block, but only up to the point where you are including all of the possible transactions that miners are likely to include.
blockreconstructionextratxn will allow the node to store more transactions which are not in the mempool, but are still valid. This increases the efficiency of compact block transmission as sometimes transactions will be evicted from your mempool but may be in other people's. This setting notably is in number of transactions, not megabytes.
maxorphantx increases transaction relay efficiency by keeping copies of transactions which could not be connected to a parent (and therefor can't be validated!), but might become valid in the future by the arrival of their parent. This setting is also in number of transactions, not megabytes.
These are about as far as you can go just by tweaking the settings in
A "hot rod", "no cost considered" Bitcoin Core node would look a bit different.
The entire UTXO would be stored in a ramdisk (to prevent a cold
dbcache ever occurring), with the obvious cost that unexpected shutdowns would result in a complete loss of synchronization state. As many cores as possible would be in use, the node would make connections to other nodes owned by the operator for maximum efficiency, and those nodes would be tuned to have as many high quality peers as possible.
You can go a long way towards making extremely performant nodes with not an unreasonable financial outlay if there's a reason to do so, it's just a matter of optimizing the right parameters and limiting bottlenecks that are normally caused by the network being optimized for stability and correctness.