In another thread I read that the little-endian notation speeds things(?) up. Has someone info on what exactly it improves for Bitcoin?

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Almost all CPUs these days work natively in little-endian. To operate on big-endian numbers, additional byteswap instructions are needed.

For most things, I think this effect is negligible. Network protocols need a convention to represent things, and Bitcoin's creator picked one. The actual choice barely matters.

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