May be a noob question but I want to develop lapps in python(django framework for the web part)? Does the implementation make a difference? If yes, how?

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All implementations have APIs against which you can easily program with any modern language. So I'd say it doesn't really matter.

However c-lightning ships with a python client called pyln or pylightning which also gives access to their low level plugin API which might be an additional reason for a python developer to select c-lightning

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