Alt-coins are now a dime a dozen and with only minor changes to generation rates, difficulty, and algorithms, they all tend to use the SHA-256 (bitcoin) or the scrypt (litecoin/tenebrix) hashing algorithms for solving blocks.
A friend of mine recently told me about Yacoin and it uses a modified version of scrypt so that mining via GPUs is currently "impossible".
What are the specific differences between the standard litecoin scrypt algorithm and the yacoin algorithm that makes yacoin currently infeasible to mine on GPUs?