You may run bitcoin-qt the very first time just executing bitcoin-qt.exe (I assume you are windows user) and make changes later
Yes, there are some useful options. For example, I do not like that this program creates database on my disk [C:] under the \users\user...\folder
I like to keep my bitcoin database in D:\bitcoin
So, I have created file bitcoin.bat with the following contents:
start bitcoin-qt.exe -datadir=d:\bitcoin
There are other options, but I think that you will find them yourself later. Default options are quite good.