BTC.com APIs are Web APIs. This means you can use them by making HTTP requests (GET/POST requests).
Like all online APIs, you can access them through whatever program/script you want, provided they are able to make HTTP requests and handle the answers.
Requests/responses are usually encoded using the JSON format.
You can find a good introduction here.
In Python you can use the 'request' package. Here you can find a quick introduction.
I wrote a generic lib to make Web API requests: https://github.com/frz-dev/webapi.js/blob/master/webapi.js