I recently bought a Nano Ledger S and have not opened or set it up yet. I read that you can use a VanityGen to create a Vanity public address. How would I do this for my Nano Ledger, if I want to make sure that I keep my keys 100% safe?

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You can't use custom keys with ledger since the addresses Ledger uses are all derived from your (randomly generated) seed.

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