I've tried running numerous Bitcoin daemon's concurrently over an NFS solution (namely LizardFS) using XFS instead of ext4. It only reached about 60% of its potential before all daemon's crashed. This 60% potential is by no means thoroughly tested and is against using SSD storage locally. I could run about 100 locally before problems arose, and 60 over LizardFS before they all crashed. I assume this was due to the write-times over a network, even though the speed was in the 20 MBs range. All CPUs, system memory, and filesystem formats were the same between my two tests.
I'm curious if running Bitcoin over IPFS is similar to the stability of local media, and how that compares to my LizardFS experience. This is particularly useful for cloud computing as the storage part of the equation can be (almost) entirely removed.